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    Zebrafish Service Platform

    2015/1/9 Viewers:
     

    Inherent ADVANTAGES of Zebrafish

       Vertebrate: zebrafish physiology, development and metabolism closely parallels mammalian systems, extremely predicitive of mammalian responses

       Genes and pathways are highly conserved: genetic homology 85% similarity with humans

       Transparency of zebrafish embryos: visualize multiple defects without dissection

       In vivo tests – compound absorption, distribution, metabolism and excretion

       Testing has short experimentation times: usually 1-7 days v.s. mouse and rat > 1month

       More cost-effective than assays using mammalian animals: $0.01/day/zebrafish v.s. $1/day/mouse

       High content/high throughput/ multiple endpoints/ automation

       Easy manipulation: external fertilization and embryogenesis – access to all stages of development

       High productivity: 100-300 embryos/couple; short generational cycles – 3 months

       Amounts of compound to be tested are very small

       Compound administrated directly into aquatic medium, large molecules can be delivered by yolk sac or circulation injection

       Fewer ethical impediments as compared to other animal models

    All BENEFITS of in vitro, with the relevance of in vivo

    In vitro/cell assay

    Zebrafish

    Mammals

    Small compound requirement

    ×

    High throughput

    ×

    Turnaround

    ×

    Relative cost

    ×

    Multiple endpoints

    ×

    PK-PD

    ×

    Activity of metabolites

    ×

      

    Integrated Zebrafish Toxicity & Safety Services

    AcuteTox

    EmbryoTox (OECD Standard)

    Developmental Tox & TeraTox

    CardioTox

    HepaTox

    NeuroTox

    Skin & muscle Tox

    OtoTox

    BoneTox

    Apoptosis

    NanoTox

     

    One-Step Shop in Zebrafish Pharmacology Studies

    Oncology

           In Vivo Anti-Angiogenesis Drug High Throughput Screening

           Novel Anti-Angiogenesis Drug Assessment

           Zebrafish Human Tumor Xenograft Model (>30 human cancer cell lines)

           Antiproliferation drug screening model

           Apoptosis models

    Ophthalmology

           Zebrafish Retinal Angiogenesis Model [for Diabetic retinopathy (DR)、Age-related macular degeneration (AMD)]

    Bone diseases

           Osteoporosis model

    Otology

           Hair cell model (assessing otoprotective agents)

    CNS

           Neuro-protectant screening model
     Pro-angiogenesis model (for stroke)

    Digestive system

           Biliary Atresia Model

    Metabolic diseases

           PLA-2 inhibitor screening model

    Skin & Pigmentation

           Skin whitening agent screening

    Regeneration

           Zebrafish Caudal Fin Regeneration Model

     
     

    Shanghai Biomodel Zebrafish Service Platform

    Shanghai Biomodel zebrafish service platform is a novel zebrafsh-based leader providing a broad range of high-quality, integrated services across both drug discovery and drug development to help pharmaceutical and biotechnology companies discover and develop novel drug candidates efficiently.

    Zebrafish Facilitiy (AAALAC Full Accreditation) and Services:

    Capacity for more than 5,000 adult fish and more than 20,000 embryos/ week. More than 7 zebrafish strains  (WT, transgenic and mutant) for different applications.

    TOXICITY AND SAFETY SERVICES: Acute toxicity, embryo toxicity, developmental toxicity & teratogenicity, organ-specific toxicity (cardiovascular, liver, nerve, bone), ototoxicity, apoptosis, nanotoxicity, etc.

    HUMAN DISEASE MODELS: Oncology, ophthalmology, bone diseases, otology, CNS, etc.

    DISCOVERY SERVICES: In Vivo Gene Function Study (Translational Medicine Research/ Target Validation)

    LIBRARY SCREENING AND DRUG REPROFILING: TCMSmall MoleculeNature Product, etc.